She was described as "the most simple woman that ever lived", but here again it was only physical.
In 1724, by the birth of her last child, Karoline had sustained an umbilical rupture causing physical complaints that were not attended to medically until, in 1737, surgical intervention became necessary.
The operation, still performed without anaesthetic, consisted merely of prodding and examining the Queen's body. At one point the Queen asked them to stop as she could not help laughing at the sight of one of the surgeon's smouldering wig from when he bent too close to a burning candle. The operation was a failure and when it became obvious she was dying, she asked her husband to remarry; but the weeping George II could only say, "Never! Never! I shall only have mistresses". Her last words were: "Pray louder that I may hear".
Half a year after Karoline's death, Amalia Sophia von Wendt came to England to become the acknowledged mistress and, in 1740, was elevated to Countess of Yarmouth. However, to show that Karoline was the only one who counted in his feelings, George II made the unusual request that their coffins be placed side by side with side-planks removed so that the two coffins were made into one to enable their bones to mingle.
 

Source: Leo van de Pas