After her mother's death, Margaret was virtually kidnapped by the King of France, and taken to France, to be raised as the bride of the Dauphin (the future Charles VIII). 
When he married Anne of Britanny instead, she was sent back to her father, Maximilian I.
 
    When she was on her way to Spain, a few years later, to marry the Infante Juan, the only son of Ferdinand of Aragon and Isabella of Castille, her ship was caught in a
storm.  Margaret did not panic; instead, she wrote an elegant couplet, and slipped it into her bracelet ( so that her body could be identified if she drowned):
 
                Ci-git Margot, la gente demoiselle/ Qu'eux deux maris, et si morut pucelle
                  (Here lies Margot, the noble maid/ Who had two husbands and never got laid)
 
    The marriage to Juan of Spain lasted only three months before the bridegroom died, supposedly of too much sex, but probably of tuberculosis ( which can sometimes cause
an increase in sexual desire).
      Margaret soon married Philibert, Duke of Savoy.  The marriage was very happy - life with Philibert was an unending round of balls and parties, tournaments and banquets
- but he soon died, in a hunting accident (!)  Margaret put on the widow's weeds familiar from most of her portraits, and never married again, although she was young and had
plenty of offers.  Instead, she devoted herself to ruling the Netherlands as Regent for her nephew, the future Emperor Charles V, and raising him and his sisters Eleanor, Mary,
Isabella. (Their brother Ferdinand and sister Catherine were being raised in Spain.)

Source: Sandra Wise