1. Princess Catherine de Braganca
            Infanta of Portugal
            Born 25 November 1638 Villa Vicosa
            Died 30 November 1705 Palace of Bemposta, Lisbon

        2. Joao IV
            King of Portugal 1640-1656
            Born 18 March 1604 Vila Vicosa
            Died 6 November 1656 Lisboa
            Married 12 January 1633 Elvas
        3. Dona Luisa de Guzman
            Regent of Portugal 1650-1662
            Born 13 October 1613 San Lucar de Barrameda
            Died 27 February 1666 Xobregaz Monastery, Lisboa

        4. Teodosio II
            7.Duque de Braganca
            Born 28 April 1568 Villa Vicosa, Evora
            Died 29 November 1630 Villa Vicosa, Evora
            Married 17 June 1603
        5. Dona Ana Fernandez de Velasco e Giron
            Born circa 1585
            Died 7 November 1607 Villa Vicosa, Evora
        6. Don Juan Manuel de Guzman El Bueno y de Silva
            8.Duque de Medina Sidonia
            Born 7 January 1579 Sanlucar de Barrameda
            Died 20 March 1636 Sanlucar de Barrameda
            Married 16 November 1598 Madrid
        7. Dona Juana de Sandoval y de La Cerda
            Born 18 August 1579 Madrid

        8. Joao I
            6.Duque de Braganca
            Born circa 1544
            Died 22 February 1583 Villa Vicosa
            Married 8 December 1563 Villa Vicosa
        9. Infanta Catharina of Portugal
            Born 18 January 1540
            Died 15 November 1614
       10. Don Juan Fernandez de Velasco
            5.Duque de Frias
            Born circa 1560
            Died 15 March 1613 Madrid
            Married 18 March 1570
       11. Dona Maria Giron
            Born February 1553 Moron de la Frontera
            Died 1608
       12. Don Alfonso de Guzman El Bueno
            7.Duque de Medina Sidonia
            Born 14 September 1549 Sevilla
            Died July 1615
            Married 3 June 1566 Madrid
       13. Dona Ana de Silva y Mendoza
            Born 11 August 1561 Madrid
            Died in Sanlucar
       14. Don Francisco de Sandoval Rojas y de Borja
            1.Duque de Lerma
            Born 1552 Tordesillas
            Died 17 May 1625 Tordesillas, Valladolid
            Married 11 May 1576 Madrid
       15. Dona Catalina de La Cerda
            Born in Cigales, Valladolid
            Died 2 June 1603

       16. Teodosio I
            5.Duque de Braganca
            Born 1510 Villa Vicosa, Evora
            Died 20 September 1563 Villa Vicosa, Evora
            Married 25 June 1542 Lisboa
       17. Dona Isabella de Castro de Portugal
            Born circa 1520 Monforte de Lemos
            Died 24 August 1558 Lisboa
       18. Duarte of Portugal
            Duke of Guimaraes
            Born 7 September 1515
            Died 20 October 1540
            Married 23 April 1537
       19. Isabella de Braganca
            Born circa 1512
            Died 16 September 1576 Villa Vicosa
       20. Inigo Fernandez de Velasco
            4.Duque de Frias
            Born circa 1530
            Died 1585
            Married 2 October 1552
       21. Dona Anna Perez de Guzman y Aragon
            Died 1589
       22. Don Pedro Giron
            1.Duque de Osuna
            Born 29 July 1537 Osuna
            Died 13 September 1590 Madrid
            Married January 1552
       23. Dona Leonor Ana Perez de Guzman y Aragon
            Born circa 1539 Sanlucar
            Died 23 November 1573
       24. Don Juan Carlos de Guzman El Bueno
            9.Conde de Niebla
            Died 1556
            Married 1541
       25. Dona Leonor Manrique de Zuniga y Sotomayor
       26. Ruy Gomez de Silva
            1.Duque de Pastrana, 1.Prince of Eboli
            Born 1516 Chamasca
            Died 29 July 1573 Madrid
            Married 18 April 1553 Madrid
       27. Anna Hurtado de Mendoza y la Cerda
            2.Princesse de Melito, 2.Duquesa de Francavilla
            Born 29 June 1540 Cifuentes, Guadalajara
            Died 2 February 1592 Pastrana, Guadalajara
       28. Don Francisco Gomez de Sandoval Rojas y Zuniga
            4.Marquess de Denia, 3.Conde de Lerma
            Died 21 March 1574
            Married 25 October 1548 Gandia
       29. Dona Isabel de Borja
            Born 1532 Medina del Campo
            Died 1558
       30. Juan II de La Cerda
            4.Duque de Medinaceli
            Died 1 August 1575
            Married 7 April 1541 / 21 January 1542 Ocanha
       31. Juana de Portugal-Norona
            Born circa 1520 Lisboa
            Died 19 June 1568 Pamplona

       32. Jayme
            4.Duque de Braganca
            Born 1479
            Died 20 September 1532 Villa Vicosa
            Married 1502
       33. Eleonore de Guzman de Mendoza
            Died 2 November 1512 Villa Vicosa
       34. Diniz de Castro de Portugal
            Conde de Lemos
            Born 1481 in Portugal
            Died 9 May 1516 Orense
            Married 1501
       35. Brites de Castro-Osorio
            6.Condesa de Lemos
            Born circa 1484
            Died 11 November 1560 Valladolid
       36. Manuel I "the Great"
            King of Portugal 1495-1521
            Born 1 June 1469 Alcocheta
            Died 13 December 1521 Lisboa
            Married 30 October 1500 Alcazar de Sal
       37. Maria of Aragon
            Born 29 June 1482 Cordova
            Died 7 March 1517 Lisboa
       38. = 32        39. = 33
       40. Don Juan de Tovar y Velasco
            1.Marques de Berlanga
            Died 1545
       41. Dona Juana Enriquez de Ribera
            Died 1576
       42. Juan Alfonso Perez de Guzman
            6.Duque de Medina Sidonia
            Died 26 November 1559 San Lucar de Barrameda
            Married 1518
       43. Anna de Aragon
       44. Don Juan Tellez Giron II 'el Santo'
            4.Conde de Urena, Senor de Osuna
            Born 1494
            Died 1558
       45. Dona Maria de la Cueva y Toledo
            Born circa 1510
            Died 1566
       46. = 42        47. = 43        48. = 42        49. = 43
       50. Francisco de Sotomayor
            5.Conde de Belalcazar
       51. Teresa de Zuniga y Guzman
            3.Duquesa de Bejar
       52. Dom Francisco Gomez da Silva
            Senor de Chamusca
            Died 1566
       53. Donha Maria de Noronha Meneses
       54. Diego Hurtado de Mendoza
            1.Prince de Melito, 1.Duque de Francavilla
            Died 15 March 1578
            Married 1538
       55. Dona Catalina de Silva y Andrade
            Condesa de Cifuentes
            Died 1576
       56. Luiz de Sandoval Rojas y Enriquez
            3.Marques de Denia
       57. Catharina de Zuniga y Enriquez
       58. St. Francisco de Borja y de Aragon
            4.Duque de Gandia
            Born 20 October 1510 Gandia
            Died 1 October 1572 Rome
            Married July 1529 Madrid
       59. Eleonora de Castro
            Born 1512 Torram
            Died 27 March 1547 Gandia
       60. Juan I de La Cerda
            2.Duque de Medinaceli
            Born 1485
            Died 20 January 1544 Cogolludo
            Married 1511
       61. Maria de Silva
            Born 1494
            Died 1544
       62. Sancho I de Portugal-Norona
            3.Conde de Odemira, 2.Conde de Faro
            Born circa 1466
            Died 1521
            Married circa 1510
       63. Angela de Fabra y Centellas
            Died after 1526 in Spain

       64. Fernando II 'Africano'
            3.Duque de Braganca, 1.Duque de Guimaraes
            Born 1430
            Died 21 June 1483 Evora (executed)
            Married 19 September 1472
       65. Isabella of Portugal
            Born 1459
            Died April 1521
       66. Juan Alfonso Perez de Guzman
            3.Duque de Medina Sidonia
       67. Isabel de Velasco
       68. = 64        69. = 65
       70. Rodrigo Henriquez de Castro-Osorio
            5.Conde de Lemos
       71. Teresa Osorio
       72. Ferdinand of Portugal
            Duke of Viseo
            Born 17 November 1433
            Died 18 September 1470 Catobriga
            Married 1452
       73. Beatrice of Portugal
            Died 30 September 1506
       74. Fernando II "the Catholic"
            King of Aragon 1479-1516
            Born 10 May 1452 Sos, Saragossa
            Died 23 January 1516 Madrigalejo
            Married 19 October 1469 Valladolid
       75. Isabella I "the Catholic"
            Queen of Castile 1474-1504
            Born 22 April 1451 Madrigalejo
            Died 26 November 1504 Medina del Campo
       76. = 64        77. = 65        78. = 66        79. = 67
       80.
       81.
       82. Fernando Enriquez de Ribera
       83. Ines Portocarrero
       84. = 66
       85. Eleonora de Zuniga
       86. Alonso de Aragon
            Archbishop of Saragossa
            Born circa 1469 /1470
            Died 1520
       87. Anna de Guerrera
       88.
       89.
       90.
       91.
       92. = 66        93. = 85        94. = 86        95. = 87
       96. = 66        97. = 85        98. = 86        99. = 87
      100.
      101.
      102.
      103.
      104.
      105.
      106.
      107.
      108. Diego Hurtado de Mendoza
            1.Conde de Melito, Viceroy of Catalunia & Valencia
            Died 5 August 1553 Toledo
      109. Ana de La Cerda
            Senora de Miedes y Mandayona
      110.
      111.
      112. Francisco Gomez de Sandoval
            2.Duque de Lerma y Uceda, Marques de Denia
      113. Felisa Enriquez de Cabrera
      114.
      115.
      116. Juan II Borgia
            3.Duque de Gandia
            Born 1494
            Died 1543
            Married 31 December 1509 Valladolid
      117. Juana de Aragon
            Died April 1521
      118. Alvaro de Castro
      119. Isabelle de Mello Barreto y Meneses
      120. Luiz II de La Cerda
            1.Duque de Medina Celi, 5.Conde de Medina Celi
            Born 1438
            Died 25 November 1501 Eriza
      121. Catherine Vique de Orejon
      122. Juan de Silva
            3.Conte de Cifuentes
            Married 1479
      123. Catherina Alvarez de Toledo
      124. Affonso de Portugal
            Conde de Odemira
            Born circa 1441
            Died 1483 Sevilla
            Married 1465
      125. Maria de Enriquez-Norona
            2.Condesa de Odemira, Seignora d'Aveiro de Vimeiro
      126. Gaspar de Fabra
            Senor de Barigadu
      127. Isabelle de Centellas y Villaragu